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The Urokinase/Urokinase Receptor System in Retinal Neovascularization: Inhibition by Å6 Suggests a New Therapeutic Target

By Paul G. Mcguire, Terence R. Jones, Nicholas Talarico, Erin Warren and Arup Das

Abstract

PURPOSE. The objective of the study was to determine the role of urokinase (uPA) and the urokinase receptor (uPAR) in retinal angiogenesis, and whether loss of uPAR or the inhibition of uPA/uPAR interactions could suppress the extent of retinal neovascularization in an animal model of ischemic retinopathy. METHODS. Retinal neovascularization was induced by exposing newborn mice to 75 % oxygen on postnatal day 7 for 5 days, followed by exposure to room air on days 12 to 17. The expression of uPAR in the retina was investigated by RT-PCR and immunohistochemistry. The role of uPAR in ischemic retinopathy was investigated by quantitating the extent of retinal neovascularization in the uPAR �/ � mouse. The effects of inhibiting the uPA/uPAR interaction on the development of retinal neovascularization were studied in this animal model with a uPA-derived peptide, Å6. Animals were treated with a

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.321.6302
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