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The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Elevated Serum Levels of Free Insulin-Like Growth Factor I in Polycystic Ovary Syndrome*

By Philip D. K. Lee, Gerry Faessen, Bart C. J. M. Fauser, Linda and C. Giudice


Polycystic ovary syndrome (PCOS) is the most common cause of anovulation in women. Previous studies suggest that the pathogenesis of PCOS may involve interrelated abnormalities of the insulinlike growth factor (IGF) and ovarian steroidogenesis systems. We investigated this hypothesis in fasting serum samples from 140 women with PCOS (age, 27.4 � 0.4 yr; body mass index, 26.3 � 0.5 kg/m 2; mean � SEM). IGF-related parameters were also studied in a group of normoovulatory women (n � 26; age, 26 � 4 yr; body mass index, 23.6 � 4.3 kg/m 2). For the PCOS group, the mean testosterone (T) level was 2.5 � 0.1 nmol/L, and it was significantly correlated with LH (r � 0.41; P � 10 �6), estrone (r � 0.33; P � 0.016), estradiol (r � 0.18; P � 0.04), and androstenedione (AD; P � 10 �6), but not with dehydroepiandrosterone sulfate (P � 0.71), a marker of adrenal steroidogenesis. T and AD were also related to total ovarian follicl

Year: 2013
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