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The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Effects of Gonadal Steroid Suppression on Skeletal Sensitivity to Parathyroid Hormone in Men*

By Benjamin Z. Leder, Matthew R. Smith, Mary Anne Fallon, Mei-ling T. Lee, Joel and S. Finkelstein

Abstract

Hypogonadism is associated with osteoporosis in men. GnRHagonist-induced hypogonadism increases bone turnover and bone loss in men, but the mechanism underlying these changes is unknown. To determine whether gonadal steroid deprivation increases the skeletal sensitivity to PTH or blunts the ability of PTH to promote 1,25dihydroxyvitamin D formation, we infused human PTH-(1–34) at a dose of 0.55 U/kg�h for 24 h, in 11 men (ages, 50–82 yr) with locally advanced, node-positive, or biochemically recurrent prostate cancer but no evidence of bone metastases. PTH infusions were performed before initiation of GnRH agonist therapy (leuprolide acetate, 22.5 mg im, every 3 months) and again after 6 months of confirmed GnRH agonist-induced hypogonadism. Serum osteocalcin (OC), bonespecific alkaline phosphatase (BSAP), N-telopeptide (NTX), wholeblood ionized calcium, and 1,25-dihydroxyvitamin D were measure

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.321.4329
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