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Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells

By Ulf Hedin, Bradford A. Bottger, Erik Forsberg, Staffan Johansson and Johan Thyberg


Abstract. Plasma fibronectin promotes modulation of rat arterial smooth muscle cells from a contractile to a synthetic phenotype during the first few days in primary culture. This process includes cell adhesion and spreading, loss of myofilaments, and formation of a widespread rough endoplasmic reticulum and a prominent Golgi complex. The structural reorganization is accompanied by activation of overall RNA and protein synthesis. Moreover, the cells gain the ability to replicate their DNA and divide in response to plateletderived growth factor. Here, it is demonstrated that the power of fibronectin to bring about this change in the differentiated properties of the smooth muscle cells resides in a 105-kD cell-binding fragment, whereas a 70-kD collagen-binding fragment and a 31-kD heparinbindin

Year: 1988
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