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Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Increased Plasma Leptin Concentration in End-Stage Renal Disease*

By Eddine Merabet, Samuel Dagogo-jack, Daniel W. Coyne, Samuel Klein, Julio V. Santiago, S. Paul Hmiel and Michael Landt


Leptin is a 16-kDa protein recently identified as the obese gene product involved in body weight regulation. Administration of recombinant leptin to ob/ob mice, which have a genetic defect in leptin production, reduces food intake and increases energy expenditure. Leptin is synthesized by fat cells, and in normal humans, plasma concentrations are proportional to adiposity. The physiological actions and the degradation pathways of leptin in humans are unknown. We investigated renal elimination of leptin by comparing plasma leptin concentrations in end-stage renal disease (ESRD) patients with normal controls. Our hypothesis was that if renal filtration is a significant route of elimination, the hormone would accumulate in ESRD patients. Mean plasma levels in 141 ESRD patients (26.8 � 5.7 and 38.3 � 5.6 �g/L for males and females, respectively) were significantly higher (P � 0.001) than mean values obtained in normal control

Year: 2013
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