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Promoter-specific ¿raws-Activationand Inhibition Mediated by.limit

By Jui-chou Hsu, Drew E. Cressman and Rebecca TaubContact The Aacr Publications, Jui-chou Hsu, Drew E. Cressman and Rebecca Taub


Nuclear levels of c-Jun,.limit. c-Fos, and LRF-1 (liver regeneration factor) are high for a large fraction of the G | phase in regenerating liver and mitogen-stimulated hepatic cells. Previously,.limit was regarded as a less potent transcriptional activator than c-Jun that could also function as a represser. However, we found that, like c-Jun,.limit alone or LRF-1/.limit strongly transactivates a cAMP-responsive promoter. Unlike c-Jun,.limit represses several AP-1 or activator of transcription factor sitecontaining promoters, and this inhibition is greatly enhanced in the pres ence of LRF-1. Here, we identify separate regions of.limit required for franv-aclivation and repression of these promoters. Deletion analysis shows that the region involved in /ran.v-activation function is highly con served among all Jun family members and corresponds to activator do main (Al) of c-Jun. In contrast, repression is maximal in the presence of both the DNA-binding domain and a region proximal to the basic region that is highly divergent among Jun proteins. Functional distinctions be tween Jun proteins during induction of the growth response and tumorigenesi

Year: 2013
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