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J Am Soc Nephrol 13: 2860–2868, 2002 A Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress

By Noritaka Kawada, Enyu Imai, Alexsander Karber, William J. Welch and Christopher S. Wilcox

Abstract

Abstract. The slow pressor response to prolonged infusions of angiotensin II (AngII) entails a delayed rise in BP. This study investigated the hypothesis that the response depends on the generation of oxidative stress. The BP and renal functional response of mice to graded doses (200, 400, and 1000 ng · kg �1 · min �1) of subcutaneously infused AngII was studied. The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by days 9 to 13 (slow pressor response) at the lower rates of AngII infusion. By day 13, there was a graded increase in SBP with the rate of AngII infusion (Vehicle

Year: 2013
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