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Regulation of Thioltransferase Expression in Human Lens

By Epithelial Cells, Nalini Raghavachari, Kostyantyn Krysan, Kuiyi Xing, Marjorie F. Lou and Invest Ophthalmol Vis Sci


PURPOSE. To study how the expression of thioltransferase (TTase), a critical thiol repair and dethiolating enzyme, is regulated in human lens epithelial cells under oxidative stress. Also to examine whether depleting the primary cellular antioxidant glutathione (GSH) in these cells has any influence on TTase expression under the same conditions. METHODS. Human lens epithelial cells (B3) were grown to confluence (1.6 million) and gradually weaned from serum in the medium before exposing to 0.1 mM H 2O 2 for 2 hours. Cell

Year: 2013
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