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Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokineactivated killer cells

By H Chambers, Nikola L Vujanovic, Albert B Deleo, Michael W. Olszowy, Ronald B Herberman, John and C Hiserodt


The in vitro activation of splenocytes or PBL with rIL-2 generates a population of cytotoxic effector cells with broad antitumor reactivity (1-4). These lymphokineactivated killer (LAK) ' cells have been suggested to be useful for the adoptive immunotherapy of metastatic tumors in animal models and in man (5-7). LAK cells have the ability to bind and lyse virtually any tumor cell, but do not lyse normal cells (1, 4, 7-10). Although LAK cells have gained much attention due to this property, very little is known about the nature of the surface structures used by LAK cells to recognize and lyse tumors. Recent evidence suggests that the majority of cells with LAK activity are derived from the NK/large granular lymphocyte (LGL) subset oflymphocytes. Many studies indicate that LAK progenitor cells from the mouse have a phenotype characteristic of NK cells, as they express asialo GMt, do not express L3T4 or Lyt-2, and as some express Thy-1 (11-14). Studies using human lymphocytes have suggested that LAK cell progenitors are mainly LGL with a CD3-, CD16 +, NKH1+, phenotype (3, 9, 10, 15-17). In the rat, the majority of LAK progenitor cells have been describe

Year: 1989
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