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et al. 1992). IL-1 decreases hCG-stimulated cAMP and testosterone formation (Calkins et al. 1988). IL-1 also reduces 8-bromo-cAMP-induced testosterone formation and hCG-induced cytochrome P450 side-chain cleavage (P450 scc) mRNA expression in rat Leydig cells (Calkins et al. 1988, Lin et al. 1991). The inhibitory effect of IL-1 can be reversed by IL-1 receptor antagonist (Lin et al. 1991). In the present study, we evaluated the expression and regulation of both StAR mRNA and protein synthesis in primary cultures of rat Leydig cells by IL-1

Year: 2013
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