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Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0309 Glucagon-Like Peptide-2 Receptor Activation in the Rat Intestinal Mucosa

By Natalie A. Walsh, Bernardo Yusta, Mark P. Dacambra, Younes Anini, Daniel J. Drucker, Patricia and L. Brubaker


Glucagon-like peptide-2 (GLP-2) increases small intestinal growth and function in rodents and human subjects. GLP-2 exerts its effects through a seven-transmembrane domain, G protein-coupled receptor (GLP-2R), stimulating cAMP generation and activating protein kinase A signaling in heterologous cell lines transfected with the GLP-2R. As intestinal cell lines expressing the GLP-2R have not been identified, we developed methods for studying GLP-2R signaling in the rat small intestinal mucosa in vitro. Isolated rat intestinal mucosal cells expressed mRNA transcripts for the GLP-2R, as well as for chromogranin A and �-tubulin III, markers for enteroendocrine and neural cells, respectively. cAMP production in response to [Gly 2]GLP-2, a degradation-resistant analog of GLP-2, was maximal at 10 �11 M (268 � 93 % of control, GLUCAGON-LIKE PEPTIDE-2 (GLP-2) is an intestina

Year: 2013
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