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Ketamine Inhibits Inositol 1,4,5-Trisphosphate Production Depending on the Extracellular Ca 2 � Concentration in Neonatal Rat Cardiomyocytes

By Akira Kudoh and Akitomo Matsuki

Abstract

We investigated the effect of ketamine on inositol 1,4,5trisphosphate (IP3) formation in rat cardiomyocytes. After the addition of 1 �mol/L ketamine, IP3 production in the presence of 0.5, 1, 5, 10, and 30 mmol/L Ca 2 � significantly decreased from 537.1 � 8.3, 590.7 � 12.9, 690.6 � 7.9, 754.8 � 12.5, and 823.7 � 15.2 pmol/mg protein t

Year: 2013
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