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0888-8809/01/$03.00/0 Molecular Endocrinology 15(10):1838–1852 Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Activation of the Phosphotyrosine Phosphatase � (r-PTP�) Is Responsible for the Somatostatin Inhibition of PC Cl3 Thyroid Cell P

By Tullio Florio, Sara Arena, Stefano Thellung, Rodolfo Iuliano, Alessandro Corsaro, Alessandro Massa, Alessandra Pattarozzi, Adriana Bajetto, Francesco Trapasso, Alfredo Fusco and Gennaro Schettini

Abstract

The aim of this study was the characterization of the intracellular effectors of the antiproliferative activity of somatostatin in PC Cl3 thyroid cells. Somatostatin inhibited PC Cl3 cell proliferation through the activation of a membrane phosphotyrosine phosphatase. Conversely, PC Cl3 cells stably expressing the v-mos oncogene (PC mos) were completely insensitive to the somatostatin antiproliferative effects since somatostatin was unable to stimulate a phosphotyrosine phosphatase activity. In PC mos cells basal phosphotyrosine phosphatase activity was also reduced, suggesting that the expression of a specific phosphotyrosine phosphatase was impaired in these transformed cells. We suggested that this phosphotyrosine phosphatas

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.319.7276
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