Skip to main content
Article thumbnail
Location of Repository

Acute Hypercapnia Improves Indices of Tissue Oxygenation More than Dobutamine in

By Septic Shock, Zhen Wang, Fuhong Su, Ro Bruhn, Xin Yang and Jean-louis Vincent


Rationale: Hypercapnia has similar hemodynamic effects to those of a dobutamine infusion and may have relevance in the management of septic shock. Objectives: To compare the effects induced by hypercapnia with those of dobutamine in a clinically relevant model of septic shock. Methods: Fecal peritonitis was induced in 21 anesthetized, invasively monitored, mechanically ventilated female sheep. A combination of Ringer’s lactate and 6 % hydroxyethyl starch solution was titrated to maintain constant cardiac filling throughout the experiments. Two hours after feces spillage, animals were randomized to one of three groups (each, n 5 7): (1) hypercapnia: carbon dioxide given to maintain partial pressure of carbon dioxide between 55 and 65 mm Hg throughout the experiment; (2) dobutamine: dobutamine infused intravenously (7 mg/kg/min); (3) control: no treatment. In the dobutamine and control groups, the partial pressure of carbo

Topics: hypercapnic acidosis, sepsis, organ failure, hyperlactatemia (Received in origina
Year: 2013
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.