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Neuro-Oncology Expression and hypoxic regulation of angiopoietins in human astrocytomas 1

By Hao Ding, Luba Roncari, Xiaoli Wu, Nelson Lau, Patrick Shannon, Andras Nagy and Abhijit Guha

Abstract

Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and edema in human astrocytomas by its interaction with cognate endothelial-speci�c receptors (VEGFR1/R2). Tie1 and Tie2/Tek are more recently identi�ed endothelial-speci�c receptors, with angiopoietins being ligands for the latter. These angiogenic factors and receptors are crucial for the maturation of the vascular system, but their role in tumor angiogenesis, particularly in astrocytomas, is unknown. In this study, we demonstrate that the angiopoietin family member Ang1 is expressed by some of the astrocytoma cell lines. In contrast to VEGF, Ang1 is down regulated by hypoxia. Ang2 was not overexpressed. Expression pro-�les of low-grade astrocytoma specimens were similar to those of normal brain, with low levels of Ang1, Ang2, and VEGF expression. Glioblastoma multiforme expressed higher levels of Ang1, but not to the same degree as pseudopalisading astrocytoma cells around necrotic and hypoxic zones expressed VEGF, as shown in previou

Year: 2000
OAI identifier: oai:CiteSeerX.psu:10.1.1.319.6680
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