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Cholesterol uptake by the ‘selective’ pathway of ovarian granulosa cells: early intracellular events

By Eve Reaven, L Louisa Tsai and Salman Azhar


Abstract Although the ‘selective ’ pathway is a major cholesteryl ester (CE) uptake pathway used by steroidogenic cells, essentially nothing is known about the itinerary of the CE once it is extracted from lipoproteins at the cell surface. In the current report we have begun to trace ‘selective ’ pathway internalized-CE using both native and reconstituted human (h) high density lipoproteins (hHDL3) with variously labeled and tagged CEs to provide information from either a biochemical or morphological perspective. It appears that the amount of hHDL3-CE that is internalized and processed through the ‘selective ’ pathway is directly related to the amount of cholesterol used for steroidogenesis at any given time point. There is a time-related correlation between the level of the BtZcAMP-stimulated cell steroidogenic response, the level of conversion of freshly obtained hHDLs-CE int

Year: 1995
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