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NAD-dependent glyceraldehyde 3-phosphate dehydrogenase

By Diego Gomez-casati, Sebastián P. Rius, Paula Casati, Alberto A. Iglesias, Diego F. Gomez-casati and Rosario Argentina

Abstract

Phosphorylating glyceraldehyde 3-phosphate dehydrogenase (GAPC-1) is a highly conserved cytosolic enzyme that catalyzes the conversion of glyceraldehyde-3-P to 1,3-bis-phosphoglycerate; besides its participation in glycolysis, it is thought to be involved in additional cellular functions. To reach an integrative view on the many roles played by this enzyme, we characterized a homozygous gapc-1 null mutant and an as-GAPC1 line of Arabidopsis thaliana. Both mutant plant lines show a delay in growth, morphological alterations in siliques and low seed number. Embryo development was altered showing abortions and empty embryonic sacs in basal and apical siliques, respectively. gapc-1 line shows a decrease in ATP levels and reduced respiratory rate. Furthermore, both lines exhibit a decrease in the expression and activity of aconitase and succinate dehydrogenase and reduced levels of pyruvate and several Krebs cycl

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.318.742
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