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Ó VSP 2000. Blood compatibility — a perspective

By Buddy D. Ratner


Research Center. This article outlines some of the history of blood contacting materials, overviews the work that has originated at the University of Washington over the past 28 years, speculates on the origins of the controversies on blood compatibility and considers the issues that should be addressed in future studies. Key words: Blood compatibility; review; perspective; hydrogel; polyurethane. A vast number of research articles and reviews have been written on the subject of blood compatibility. The widespread clinical application of devices that contact blood provide both humanitarian and � nancial sides to any discussion of this topic. Finally, there is considerable intellectual richness and excitement in this area of exploration. Three subjects dominate the blood–materials interaction literature. (1) How can we measure blood compatibility? (2) What biomaterials are blood compatible? (3) What is the biological basis of the reaction of materials with blood. In spite of the extensive body of literature developed over some 35 years, there is little consensus on points (1) and (2) and just faint glimmers of progress on point (3)

Year: 2000
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