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Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task

By Janusz Rajkowski, Henryk Majczynski, Edwin Clayton and Gary Aston-jones

Abstract

Gary Aston-Jones. Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task. J Neurophysiol 92: 361–371, 2004. First published March 17, 2004; 10.1152/jn.00673.2003. We previously reported that noradrenergic neurons in the monkey locus coeruleus (LC) are activated selectively by target stimuli in a target detection task. Here, we varied the discrimination difficulty in this task and recorded impulse activity of LC neurons to analyze LC responses on error trials and in relation to behavioral response times (RTs). In easy and difficult discrimination conditions, LC neurons responded preferentially to target stimuli with phasic activation. These responses consistently preceded behavioral responses regardless of task difficulty. Latencies for LC and behavioral responses increased similarly for difficult compared with easy discrimination trials. LC response latencies were also shorter for fast RT trials compared with slow RT trials regardless of difficulty

Year: 2004
DOI identifier: 10.1152/jn.00673.2003.
OAI identifier: oai:CiteSeerX.psu:10.1.1.318.5169
Provided by: CiteSeerX
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