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The Hsp90 chaperone complex as a novel target for cancer therapy

By M. P. Goetz, D. O. Toft, M. M. Ames and C. Erlichman


Background: Heat shock protein 90 (Hsp90) is responsible for chaperoning proteins involved in cell signaling, proliferation and survival. 17-allylamino-17-demethoxygeldanamycin (17-AAG) is an anticancer agent currently in phase I trials in the USA and UK. It represents a class of drugs, the benzoquinone ansamycin antibiotics, capable of binding and disrupting the function of Hsp90, leading to the depletion of multiple oncogeni

Year: 2003
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