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Mechanims of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals. Cancer Res

By Joanne P. Marsh and Brooke T. MossmanContact The Aacr Publications, Epithelial Cells, Asbestiform Minerals, Joanne P. Marsh and Brooke T. Mossman

Abstract

Asbestos induces a constellation of biological responses in cells of the respiratory tract that are similar to those of classical tumor promoters. In this regard, induction of ornithine decarboxylase (ODC) activity and increased incorporation of |3H]thymidine have been documented after addition of crocidolite and chrysotile asbestos to a hamster trachea! epithelial cell line (J. M. Landesman and B. T. Mossman, Cancer Res., 42:3669-3675, 1982). The objectives of studies here were to determine: (a) the importance of geometry, size, and/or chemical composition of asbestos fibers on induction of ODC activity; and (b) the possible involvement of calcium and/or protein kinase C in asbestos-induced ODC activity. After addition for 24 h to confluent hamster trachea! epithelial cells, fibers of crocidolite, chrysotile, and glass in medium containing fresh serum caused a significant increase in ODC activity. Stimulation of ODC was not observed when nonfibrous analogues (riebeckite, antigorite

Year: 1998
OAI identifier: oai:CiteSeerX.psu:10.1.1.318.3163
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