Article thumbnail
Location of Repository

Intravenous Dexmedetomidine Inhibits Cerebrovascular Dilation Induced by Isoflurane and Sevoflurane in Dogs

By Hiroto Ohata


Our aim in this study, performed using a closed cranial window preparation, was to investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane or sevoflurane. After instrumentation under pentobarbital anesthesia, 48 dogs were assigned to one of two groups: the isoflurane group or the sevoflurane group (n � 24 each). Twenty-four dogs received saline (n � 6) or one of three different doses of dexmedetomidine (0.5, 1.0, or 2.0 �g/ kg) (n � 6 each) IV. Animals were then exposed to three different minimum alveolar anesthetic concentrations (MACs; 0.5, 1.0, and 1.5) of either isoflurane or sevoflurane. Cerebrovascular diameters were measured at each stage. Pretreatment with dexmedetomidine decreased pial vessel diameters. Both isofluran

Year: 2013
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • http://www.anesthesia-analgesi... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.