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Intravenous Dexmedetomidine Inhibits Cerebrovascular Dilation Induced by Isoflurane and Sevoflurane in Dogs

By Hiroto Ohata

Abstract

Our aim in this study, performed using a closed cranial window preparation, was to investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane or sevoflurane. After instrumentation under pentobarbital anesthesia, 48 dogs were assigned to one of two groups: the isoflurane group or the sevoflurane group (n � 24 each). Twenty-four dogs received saline (n � 6) or one of three different doses of dexmedetomidine (0.5, 1.0, or 2.0 �g/ kg) (n � 6 each) IV. Animals were then exposed to three different minimum alveolar anesthetic concentrations (MACs; 0.5, 1.0, and 1.5) of either isoflurane or sevoflurane. Cerebrovascular diameters were measured at each stage. Pretreatment with dexmedetomidine decreased pial vessel diameters. Both isofluran

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.318.2980
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