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Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Expression and Secretion of Inhibin and Activin in Normal and Neoplastic Uterine Tissues. High Levels of Serum Activin A in Women with Endometrial

By Cervical Carcinoma, Felice Petraglia, Pasquale Florio, Stefano Luisi, Rosita Gallo, Angiolo Gadducci, Paola Viganò, Anna Maria, Di Blasio, Andrea R. Genazzani and Wylie Vale


Inhibins and activins are growth factors belonging to the transforming growth factor-�) family and are known to influence cell proliferation and differentiation. Because transforming growth factor-� is involved in physiological and tumoral changes of uterine tissues, the present study aimed to evaluate whether human normal and neoplastic endometrial and cervical epithelial cells express and secrete inhibin A, inhibin B, and activin A. To test this hypothesis, different approaches were used. By RT-PCR, the expression of specific messenger RNAs (mRNAs) for the inhibin �, activin �A and �B subunits, and activin receptor type II and type IIB was investigated: 1) in primary cultures of endometrial (stroma and epithelium) or cervical (epithelium) cells from healthy women; and 2) in specimens of endometrial or cervical carcinoma. To demonstrate a possible secretion of the proteins, dimeric inhibin A

Year: 2013
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