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The Serum and Glucocorticoid-Inducible Kinase SGK1 and the Na � /H � Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K � Channel ROMK1

By C. Chris Yun, Monica Palmada, Hamdy M. Embark, Olga Fedorenko, Yuxi Feng, Guido Henke, Iwan Setiawan, Christoph Boehmer, Edward J. Weinman, Sabrina Sandrasagra, Christoph Korbmacher, Philip Cohen, David Pearce and Florian Lang


Abstract. Mineralocorticoids stimulate Na � reabsorption and K � secretion in principal cells of connecting tubule and collecting duct. The involved ion channels are ENaC and ROMK1, respectively. In Xenopus oocytes, the serum and glucocorticoid-sensitive kinase SGK1 has been shown to increase ENaC activity by enhancing its abundance in the plasma membrane. With the same method, ROMK1 appeared to be insensitive to regulation by SGK1. On the other hand, ROMK1 has been shown to colocalize with NHERF2, a protein mediating targeting and trafficking of transport proteins into the cell membrane. The present study has been performed to test whether NHERF2 is required for regulation of ROMK1 by SGK1. Coexpression of neither NHERF2 nor SGK1 with ROMK1 increases ROMK1 activity. However, coexpression of NHERF2 and SGK1 together with ROMK1 markedly increase

Year: 2013
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