This article has an online data supplement, which is accessible from this issue's table of content online at www.atsjournals.org Acid-base disturbances such as metabolic or respiratory alkalosis are relatively common in critically ill patients. We examined the effects of alkalosis (hypocapnic or metabolic alkalosis) on alveolar fluid reabsorption in the isolated and continuously perfused rat lung model. We found that alveolar fluid reabsorption after 1 hour was impaired by low levels of pCO2 (10 and 20 mmHg) independent of pH levels (7.7 or 7.4). Additionaly, pCO2 higher of 30 mmHg or metabolic alkalosis did not have an effect on this process. The hypocapnia-mediated decrease of alveolar fluid reabsorption was associated with decreased Na,K-ATPase activity and protein abundance at the basolateral membranes of distal airspaces. The effect of low pCO2 on alveolar fluid reabsorption was reversible as clearance normalized after correcting the pCO2 back to normal levels. These data suggest that hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Conceivably, correction of hypocapnic alkalosis in critically ill patients, ma
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