Location of Repository

Activity-Dependent Patterning of Retinogeniculate Axons Proceeds with a Constant Contribution from AMPA and NMDA Receptors

By Carsten D. Hohnke, Serkan Oray and Mriganka Sur


Neural activity is critical for the refinement of neural circuitry during development, although the mechanisms involved in stabilizing appropriate connectivity remain unclear. It has been proposed that the insertion of AMPA receptors at synapses with only NMDA receptors (“silent synapses”) mediates this stabilization, leading to an increasing contribution from AMPA receptors as development proceeds. Here we show in a mammalian system known to undergo activity-dependent development [the segregation of retinal afferents into ON/OFF sublaminae in the ferret lateral geniculate nucleus (LGN)] that the refinement of the neural circuitry occurs in the presence of a constant functional contribution from AMPA and NMDA receptors. Although we detected a small number of silent synapses on LGN cells, their proportion did not decrease with age. The size and kinetics of NMDAmediated spontaneous EPSCs (sEPSCs) were also stable ove

Year: 2013
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://www.jneurosci.org/conte... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.