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The Biological Effeds of Antisense N-myc Expression in Human Neuroblastoma’

By Mary Lou Schmidt, Helen R. Salwen, Chitra F. Manohar, Naohiko Ikegaki and Susan L. Cohn


Although N-myc amplification and overexpression are believed to play an important role in determining the clinical behavior of neuroblastoma (NB), the exact function of N-myc in NB cell growth and differentiation remains unknown. To better understand the function of N-myc, an established human NB cell line was transfected with N-myc antisense (AS) complementary DNA in an effort to down-regulate N-myc gene expression. Five clones expressing AS N-myc RNA have been maintained in culture for over 2 years. Compared to control cells, a 30-69 % decrease in the quantity of N-myc protein was demonstrated by Western blo

Year: 2013
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