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SULFATION AND SULFOTRANSFERASES 1 Sulfotransferase molecular biology: cDNAs and genes

By Richard M. Weinshilboum, Diane M. O’vferness, Ibrahim A. Aksoy, Thomas C, Chengtao Her, Rebecca and B. Raffogianis


As has occurred in most fields, rapid progress has been made in our understanding of the molecular structure of the cDNAs and genes for the cytosolic sulfotransferases. More than 30 ST cDNAs have been isolated from several vertebrate species as well as from plants. These enzymes share significant sequence homology at both the level of the cDNAs as well as in their intronlexon structure, suggesting that the cytosolic STs have evolved from a common ancestral gene. The continued characterization of both the ST cDNAs and the structural genes that encode them will provide insights into the possible mechanisms of regulation of expression of the different forms as well as the basis for the allelic differences observed in the expression of the STs. We can expect that the number of ST cDNAs will increas

Year: 2013
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