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World Academy of Science, Engineering and Technology 38 2010 Function of miR-125b in Zebrafish

By Minh T. N. Le, Cathleen Teh, Ng Shyh-chang, Vladimir Korzh, Harvey F. Lodish and Bing Lim

Abstract

Abstract—MicroRNAs are an important class of gene expression regulators that are involved in many biological processes including embryogenesis. miR-125b is a conserved microRNA that is enriched in the nervous system. We have previously reported the function of miR-125b in neuronal differentiation of human cell lines. We also discovered the function of miR-125b in regulating p53 in human and zebrafish. Here we further characterize the brain defects in zebrafish embryos injected with morpholinos against miR-125b. Our data confirm the essential role of miR-125b in brain morphogenesis particularly in maintaining the balance between proliferation, cell death and differentiation. We identified lunatic fringe (lfng) as an additional target of miR-125b in human and zebrafish and suggest that lfng may mediate the function of miR-125b in neurogenesis. Together, this report reveals new insights into the function of miR-125b during neural development of zebrafish. Keywords—microRNA, miR-125b, neurogenesis, zebrafish. I

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.309.9966
Provided by: CiteSeerX
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