İloprost ve pentoksifilin tavflan modelinde iskelet kasındaki iskemi-reperfüzyon hasarını hafifletir
Abstract
BACKGROUND: We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-reperfusion injury in a rabbit model. METHODS: Forty New Zealand white rabbits were grouped into four. In Group 1, iloprost was continuously infused starting half an hour before the reperfusion following a 2-hour ischemia formed by abdominal aortic occlusion, and it was continued during the 4-hour reperfusion period. Group 2 was treated with pentoxifylline, and Group 3 received saline solution. Group 4 was the sham group. Malondialdehyde levels and edema scores in gastrocnemius muscle were evaluated. RESULTS: Edema score was significantly lower in Group 1 when compared with the control group (Group 1 vs Group 3, p=0.040; Group 2 vs Group 3, p=0.145; Group 1 vs Group 2, p=0.580). Malondialdehyde levels of the medicated groups were significantly lower when compared with the control group (Group 1: 60±11 nmol/g tissue, Group 2: 74±11 nmol/g tissue, Group 3: 95±10 nmol/g tissue; Group 1 vs Group 2, p=0.010; Group 1 vs Group 3, p<0.001; Group 2 vs Group 3, p<0.001; Group 1 vs Group 4, p<0.001; Group 2 vs Group 4, p<0.001; Group 3 vs Group 4: p<0.001). CONCLUSION: Acute skeletal muscle ischemia is a common problem. We are of the opinion that in the early phase of skeletal muscle ischemia, iloprost and pentoxifylline medication may reduce ischemia-reperfusion injury- Article
- Cardiovascular agents
- Iloprost
- Ischemia-reperfusion injury/drug therapy
- Pentoxifylline
- Rabbit skeletal muscle
- iloprost
- malonaldehyde
- pentoxifylline
- abdominal aorta
- animal experiment
- animal model
- animal tissue
- aorta occlusion
- article
- continuous infusion
- controlled study
- edema
- female
- gastrocnemius muscle
- male
- muscle ischemia
- nonhuman
- rabbit
- reperfusion injury
- Animals
- Disease Models, Animal
- Drug Therapy, Combination
- Edema
- Female
- Humans
- Male
- Malondialdehyde
- Muscle, Skeletal
- Platelet Aggregation Inhibitors
- Rabbits
- Random Allocation
- Reperfusion Injury
- Treatment Outcome
- Vasodilator Agents