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Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of

By Acinetobacter Baumannii, Pauline D. Mugnier, Laurent Poirel, Thierry Naas and Patrice Nordmann

Abstract

To assess dissemination of OXA-23–producing strains of Acinetobacter baumannii, we obtained 20 carbapenemresistant, OXA-23–producing isolates from different regions. Their clonal relationship was assessed by pulsed-fi eld gel electrophoresis and multilocus sequence typing. We identifi ed 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The bla OXA-23 gene was either located on the chromosome or on plasmids and associated with 4 genetic structures. Acinetobacter baumannii is a gram-negative organism that is increasingly recognized as a major pathogen causing nosocomial infections, including bacteremia and ventilator-associated pneumonia, particularly in patients admitted to intensive care units (1). Several studies have shown the geographically widespread occurrence of multidrug-resistant A. baumannii strains, which suggested a clonal relatedness of these strains. Three international A. baumannii clones associated with multidrug resistance (European clones I, II, and III) have been reported (2). Increasing resistance to carbapenems has been observed worldwide in the past decade, frequently mediated by production of class D β-lactamases with carbapenemase activity. Three acquired class D β-lactamases with carbapenemase gene clusters have been described in A. baumannii, which correspond to bla-like, bla-like, and OXA-23 OXA-40 bla-like genes (3). The bla gene, first character

Year: 2013
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