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Mitochondrial dysfunction leads to telomere attrition and genomic instability

By Lin Liu, James R. Trimarchi, Peter J. S. Smith and David L. Keefe

Abstract

Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging-associated pathologies. Telomere shortening and genomic instability have also been associated with replicative senescence, aging and cancer. Here we show that mitochondrial dysfunction leads to telomere attrition, telomere loss, and chromosome fusion and breakage, accompanied by apoptosis. An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria, suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability. Further, nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria. This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies.<br/><br/

Topics: QH301, QH426
Year: 2002
OAI identifier: oai:eprints.soton.ac.uk:188837
Provided by: e-Prints Soton
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