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The pharmacological basis for rational use of atabrine in treatment of malaria

By James A. Shannon, David P. Earle, Bernard B. Brodie, John V, Robert W. Berliner, Tee Resident, Rarr Or and T He


Present usage of atabrine in the suppression and tre&ment of malaria is largely empirical. Until recently (l), regimes of therapy appeared to be constructed so aa to obtain a therapeutic effect roughly equivalent to that of quinine and at the same time to minimize the hazard of toxic reactions (2). Such an approach to the general problem of atabrine therapy is a striking contrast to the more quantitative one which has facilitated the development of sound antibacterial therapy with the sulfonamide. The availability of relatively simple methods for the estimation of atabrine concentration in biological fluids (3, 4) now permits the latter type of approach to the problems of atabrine Jherapy. The observations transmitted in this report are derived from studies which examine certain aspects of the fate of atabrine in the body under several general circumstances. The fundamental,premise, underlying these and other similar studies, is that the antimalarial activity of atabrine may be related to its concentration in the plasma, or, perhaps more precisely, to the concentration of unbound drug in plasma water. Some general support of this thesis will be found in the data of this report. More-direct evidence will be presented in other communcations (5). The report is divided into three sections. The fust is concerned with the physiological disposition of atabrine in the body. It details observations made on the dog and on man which outline that part of the general pharmacology o

Year: 1944
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