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Whirling Platelets Away for Transfusion

By Camelia Iancu-Rubin, Ronald Hoffman and Anna Rita* Migliaccio

Abstract

With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs. With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs

Topics: Biochemistry, Genetics and Molecular Biology (all)
Publisher: 'Elsevier BV'
Year: 2018
DOI identifier: 10.1016/j.cell.2018.07.018
OAI identifier: oai:cris.unibo.it:11585/661641
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