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Complexation of DNA with Cationic Surfactant

By Paulo S. Kuhn, Marcia C. Barbosa and Yan Levin

Abstract

Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements. PACS.05.70.Ce- Thermodynamic functions and equations of state PACS.61.20.Qg- Structure of associated liquids: electrolytes, molten salts, etc. PACS.61.25.Hq- Macromolecular and polymer solutions; polymer melts; swelling Corresponding author

Year: 1999
OAI identifier: oai:CiteSeerX.psu:10.1.1.305.4787
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