Satisfaction with antiepileptic drugs in children and adolescents with newly diagnosed and chronic epilepsy
July 24, 2015
none13PURPOSE: To assess incidence, indicators and
outcome of satisfaction with antiepileptic drugs in
METHODS: Multicenter, observational, open,
prospective survey of children and adolescents with
epilepsy with three-month follow-up. Included were
patients aged 3-17 years with newly diagnosed ("new
diagnosis") or chronic epilepsy ("old diagnosis")
requiring treatment start or change. Satisfaction was
assessed with the Hedonic Visual Scale or direct
questions, depending on patient's age. Quality of life
of adolescents (QOLIE-48) and of caregivers (SF-36)
and predictors of (dis)satisfaction were also assessed.
RESULTS: 293 patients completed the study. Most had
generalized idiopathic epilepsy, and a disease lasting
<12 months. Newly diagnosed patients were 60.8%.
Patients declaring satisfaction were 70.6% at one
month and 75.8% at three months. Compared to old
diagnosis, new diagnosis carried a higher satisfaction
rate and improved satisfaction at end of follow-up.
Independent predictors of dissatisfaction were an old
diagnosis, adverse events and SF-36 score. The latter
remained the only independent predictor of persisting
dissatisfaction when adjusting for the presence of and
the interaction with adverse events.
CONCLUSIONS: About one-fourth of children and
adolescents with epilepsy are dissatisfied with
treatment. Chronic epilepsy, adverse events, and
parents/caregivers with poor quality of life predict
dissatisfaction.noneE. Beghi; P. Messina; E. Pupillo; G. Crichiutti; M.G. Baglietto; P. Veggiotti; N. Zamponi; S. Casellato; L. Margari; C. Cianchetti; the TASCA study group [...; A. Parmeggiani; ...]E. Beghi; P. Messina; E. Pupillo; G. Crichiutti; M.G. Baglietto; P. Veggiotti; N. Zamponi; S. Casellato; L. Margari; C. Cianchetti; the TASCA study group [..; A. Parmeggiani; ..