PHOSPHATE ESTER FLAME RETARDANTS

Abstract

MRLs are substance specific estimates, which are intended to serve as screening levels, are used by ATSDR health assessors and other responders to identify contaminants and potential health effects that may be of concern at hazardous waste sites. The international and national regulations, advisories, and guidelines regarding phosphate ester flame retardants in air, water, and other media are summarized in Table 8-1. ATSDR has derived an intermediate-duration oral MRL of 0.6 mg/kg/day for TCEP based on an increased incidence of brain lesions in female Fischer-344 rats dosed by gavage 5 days/week for 16 weeks (NTP 1991a). The MRL was derived using benchmark modeling of incidence data for brain lesions in female rats. The predicted dose associated with a 10 % extra risk (BMD10) for brain lesions was 143.41 mg/kg/day; the lower 95 % confidence limit on this dose (BMDL10) was 85.07 mg/kg/day. An uncertainty factor of 100 was used (10 for animal to human extrapolation and 10 for human variability). ATSDR has derived a chronic-duration oral MRL of 0.2 mg/kg/day for TCEP based on an increased incidence of renal tubule epithelial hyperplasia in female Fischer-344 rats dosed by gavage 5 days/week for 2 years (NTP 1991a). The MRL was derived using benchmark modeling of incidence data for renal lesions in female rats. The BMD10 for renal lesions was 48.00 mg/kg/day; the BMDL10 wa

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