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Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue

By S. Loerakker, A. Stekelenburg, G.j. Strijkers, J.J.M. Rijpkema, F.P.T. Baaijens, D.L. Bader, K. Nicolay and C.W.J. Oomens

Abstract

Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury. Recently, by means of an experimental-numerical approach, it was shown that local tissue deformations cause tissue damage once a deformation threshold is exceeded. In the present study, the effects of load exposure time and intermittent load relief on the development of deformation-induced muscle damage were investigated. The data showed that a 2 h loading period caused more damage than 10 min loading. Intermittent load reliefs of 2 min during a 2 h loading period had minimal effect on the evolution of skeletal muscle damage. In addition, a local deformation threshold for damage was found, which was similar for each of the loading regimes applied in this study. For short loading periods, these results imply that local tissue deformations determine whether muscle damage will develop and the exposure time influences the amount of tissue damage. Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading period

Topics: R1
Year: 2010
OAI identifier: oai:eprints.soton.ac.uk:189381
Provided by: e-Prints Soton

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  1. (2006). A new MR-compatible loading device to study in-vivo muscle damage development in rats due to compressive loading. doi
  2. (2003). A specialist seating assessment clinic: changing pressure relief practice. doi
  3. (2005). Analysis of ischemia-reperfusion injury in a microcirculatory model of pressure ulcers. Wound Repair Regen. doi
  4. (2000). Applied Logistic Regression, 2nd edn. doi
  5. (2003). Compression induced cell damage in engineered muscle tissue: an in vitro model to study pressure ulcer aetiology. doi
  6. (2008). Compression-induced damage and internal tissue strains are related. doi
  7. (2006). Compression-induced deep tissue injury examined with magnetic resonance imaging and histology.
  8. (2001). Compressive deformation and damage of muscle cell subpopulations in a model system. doi
  9. (1996). Computing strain fields from discrete displacement fields in 2d solids. doi
  10. (2006). Fundamentals of Biostatistics, 6th edn. Thomson Brooks/Cole,
  11. (2005). In vivo muscle stiffening under bone compression promotes deep pressure sores. doi
  12. (1996). In: Encyclopedia of Nuclear Magnetic Resonance. doi
  13. (2000). Ischemia-reperfusion injury in chronic pressure ulcer formation: a skin model in the rat. Wound Repair Regen. doi
  14. (1981). Lymphatic clearance during compressive loading.
  15. (2007). Measuring tissue perfusion during pressure relief maneuvers: insights into preventing pressure ulcers.
  16. (2007). National pressure ulcer advisory panel’s updated pressure ulcer staging system. doi
  17. (2001). Passive transverse mechanical properties of skeletal muscle under in vivo compression. doi
  18. (2001). Prevention and treatment of pressure ulcers: What works? What doesn’t?
  19. (2009). Reswick and rogers pressure-time curve for pressure ulcer risk. Part 2. doi
  20. (2007). Role of ischemia and deformation in the onset of compression-induced deep tissue injury: MRI-based studies in a rat model. doi
  21. (2007). Strains and stresses in subdermal tissues of the buttocks are greater in paraplegics than in healthy during sitting. doi
  22. (2001). The effect of gradually increased blood flow on ischemia-reperfusion injury. doi
  23. (2007). The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study. doi
  24. (2007). Understanding diagnostic tests 3: receiver operating characteristic curves. doi
  25. (2008). Validation of a numerical model of skeletal muscle compression with MR tagging: a contribution to pressure ulcer research. doi
  26. (2008). Validationof anumerical modelof skeletalmuscle compression with MR tagging: a contribution to pressure ulcer research. doi

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