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NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

By RUBERTI F, BERRETTA N, CATTANEO A and CHERUBINI E.

Abstract

Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse

Year: 1997
OAI identifier: oai:ricerca.sns.it:11384/4152
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