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ORIGINAL ARTICLE Early Metabolic Flare in Squamous Cell Carcinoma after Chemotherapy is a Marker of Treatment Sensitivity In Vitro

By Maria Bjurberg, Parisa Abedinpour, Eva Brun, Elisabeth Kjellén, M. Bjurberg, E. Brun and E. KjellénP. Abedinpour, P. Borgström, B. Baldetorp, J. Wennerberg and E. Kjellén

Abstract

# The Author(s) 2010. This article is published with open access at Springerlink.com Purpose Early metabolic response with a decrease in glucose demand after cytotoxic treatment has been reported to precede tumor volume shrinkage. However, preclinical studies report of a very early rise in metabolism, a flare, following treatment. To elucidate these observations, we performed an experimental study on early metabolic response with sequential analysis of metabolic changes. Methods Three squamous cell carcinoma cell lines and one nontumorigenic cell line were exposed to cisplatin. The uptake of the fluorescent glucose analogue 2-NBDG was examined at days 1–6 using fluorescence microscopy. The relation between 2-NBDG-uptake and cell survival was evaluated. M. Bjurberg and P. Abedinpour contributed equally to this wor

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.292.5316
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