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Research | Children’s Health Organophosphate Pesticide Exposure and Attention in Young Mexican-American Children: The CHAMACOS Study

By Amy R. Marks, Kim Harley, Asa Bradman, Katherine Kogut, Dana Boyd Barr, Caroline Johnson, Norma Calderon and Brenda Eskenazi

Abstract

associated with neurobehavioral deficits in children. Objectives: We investigated whether OP exposure, as measured by urinary dialkyl phosphate (DAP) metabolites in pregnant women and their children, was associated with attention-related outcomes among Mexican-American children living in an agricultural region of California. Me t h o d s: Children were assessed at ages 3.5 years (n = 331) and 5 years (n = 323). Mothers com‑ pleted the Child Behavior Checklist (CBCL). We administered the NEPSY-II visual attention sub‑ test to children at 3.5 years and Conners ’ Kiddie Continuous Performance Test (K-CPT) at 5 years. The K-CPT yielded a standardized attention deficit/hyperactivity disorder (ADHD) Confidence Index score. Psychometricians scored behavior of the 5-year-olds during testing using the Hillside Behavior Rating Scale. Res u l t s: Prenatal DAPs (nanomoles per liter) were nonsignificantly associated with maternal report of attention problems and ADHD at age 3.5 years but were significantly related at age 5 years [CBCL attention problems: β = 0.7 points; 95 % confidence interval (CI), 0.2–1.2; ADHD: β = 1.3; 95 % CI, 0.4–2.1]. Prenatal DAPs were associated with scores on the K-CPT ADHD Confidence Index> 70th percentile [odds ratio (OR) = 5.1; 95 % CI, 1.7–15.7] and with a composite ADH

Year: 2013
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