Owing to its rarity, large-scale retrospective studies in male breast cancer have suffered from the small numbers of cases available for study from any one center. Here we describe our experience in establishing a large collection of male breast cancers in tissue micro array format suitable for biomarker analysis by immunohistochemistry. Male breast tissue lies posterior to the nipple on the chest wall. It is generally considered nonfunctional; while lactation is physiologically possible it is very rare, requiring specific hormonal cues. 1 Although not exposed to the same cyclical hormones as the pre-meno pausal female breast, male breast epithelium is not immune to DN
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