VOLUME BRIEF NOTES CARBAMYLCHOLINE PREVENTS GIANT GRANULE FORMATION IN CULTURED FIBROBLASTS FROM BEIGE (CHEDIAK-HIGASHI) MICE

Abstract

The Chediak-Higashi (CH) 1 syndrome is an inherited disorder of humans (2) and certain mutant strains of mice (1, 7), mink (I 1), and cattle (16). It is characterized by partial oculocutaneous albinism, increased susceptibility to pyogenic infections, and several functional abnormalities of leukocytes including defective lysosomal degranulation and impaired chemotaxis (24). An accelerated phase of the disease, diagnosed as a lymphoma-like malignancy, commonly occurs in man (2). The presence of giant granules in virtually all granule-containing cells is pathognomonic of the disease. We recently described an abnormality of concanavalin A (Con A) distribution on polymorphonuclea

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