10.1084/jem.62.4.573

CUTANEOUS REACTIVITY OF IMMUNE AND HYPERSEN- SITIVE RABBITS TO INTRADERMAL INJECTIONS OF HOMOLOGOUS INDIFFERENT STREPTOCOCCUS AND ITS FRACTIONS

Abstract

It is now well established that rabbits can be made hypersensitive by repeated intracutaneous injections of streptococci so that subsequent inoculations induce enormously exaggerated skin lesions (1--6); and it is also known that rabbits immunized by suitable intravenous injections of the same microorganisms show lesions smaller than normal at subsequent skin tests (7, 8). The purposes of the present study were: (a) to observe the types of dermal reactions induced in such bacterially hypersensitive and immune rabbits by different chemical fractions of the homologous cocci, and (b) to investigate the relationship between these reactions and the circulating antibodies. The work was undertaken in three separate experiments, but, since the basic technique was the same in each, the methods and results will be described together, with special notation where exceptions were encountered. W.XPERIMENTA

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