PRESSOR SUBSTANCES FROM THE BODY FLUIDS OF MAN IN HEALTH AND DISEASE*

Abstract

It has been a theory of long standing that high blood pressure is due to circulation of a pressor substance acting on the peripheral blood vessels. Convincing proof either for or against this conception does not appear to have been established. It seemed to us, therefore, that the problem was worthy of intensive study. Much has been written on the subject of pressor substances in blood, but due to the fact that the methods employed in the preparation and testing of the extracts are so divergent, only certain of them need be considered here. Vasoconstrictor substances in the alcoholic extract of blood from hypertensive patients have perhaps been demonstrated (1, 3, 9, 10), but their presence has been denied (11-13). Bohn (9, 10) prepared alcoholic extracts of blood and tested them on curarized cats, anesthetized with ethyl urethane. He concluded that a pressor substance was present in the blood of patients suffering from nephritic hypertension, from edampsia, and from malignant nephrosderosis, but, without exception, bloo

Similar works

This paper was published in CiteSeerX.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.