IMMUNOCHEMICAL STUDY OF ANTIGENIC SPECIFICITY IN DELAYED HYPERSENSITIVITY IV. THE PRODUCTION OF UNRESPONSIVENESS TO DELAYED HYPERSENSITIVITY WITH A SINGLE ANTIGENIC DETERMINANT*

Abstract

Immunological specificity for delayed skin reactions, as well as for circulating antibody, has been investigated with many haptens coupled to antigenic protein carriers (1). With these antigens, hapten-specific antibodies were formed consistently, whereas delayed reactions were produced only with the immunizing antigen and not with conjugates of the same hapten with a different cartier protein. Thus, there was marked carrier specificity for delayed hypersensitivity reactions, as opposed to the hapten specifiicty of antibody-induced reactions (2, 3). In contrast to this, when arsanilic acid as the hapten is coupled to an apparently non-antigenic carrier such as polytyrosine, the specificity for delayed hypersensitivity is directed predominantly towards the hapten alone (4). Further confirmation of the specificity of these reactions was shown by the successful desensitization achieved with a variety of conjugates of arsanilic acid (5). Because of the hapten-specific nature of this phenomeon, it was felt that the same system would provide a useful tool to investigate the specificity of immunologic unresponsiveness or tolerance. A further advantage of polytyrosine-azobenzenearsonate as an antigen fo

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