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A simple method, inspired by procedures used in physics of nuclear multifragmentation, allows to establish order of precedence and age of pairs of haplotypes separated by one mutation. For both haplotypes of the pair, searches for existing haplotypes, differing by increasing number of mutations, are carried out using a database. The resulting ratios of frequences of haplotypes, found at given mutation distances, are compared to calculated probability ratios. The order of precedence and age of the pair of haplotypes can be deduced when the resulting ratios follow hyperbolic dependence. Method can be used with relatively small and not necessarily complete samples, using publicly accessible databases.Comment: LaTeX, 10 pages, 5 figure

Topics:
Physics - Data Analysis, Statistics and Probability, Nuclear Experiment, Quantitative Biology - Populations and Evolution

Year: 2011

OAI identifier:
oai:arXiv.org:1103.0878

Provided by:
arXiv.org e-Print Archive

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