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Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules

By Veikko Linko, Jenni Leppiniemi, Boxuan Shen, Einari Niskanen, Vesa P. Hytönen and J. Jussi Toppari

Abstract

We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.Comment: 5 pages, 3 figures; Nanoscale (2011

Topics: Physics - Biological Physics, Condensed Matter - Other Condensed Matter, Condensed Matter - Soft Condensed Matter
Year: 2011
DOI identifier: 10.1039/c1nr10518c
OAI identifier: oai:arXiv.org:1102.4594
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