Skip to main content
Article thumbnail
Location of Repository

Impact of symptoms on quality of life before and after diagnosis of coeliac disease: results from a UK population survey

By Alastair M. Gray and Irene Papanicolas


Background: Coeliac disease is a common chronic autoimmune disorder. Underdiagnosis is common and the quality of life impact of symptoms may be severe. We report a study of symptom duration and quality of life before and after diagnosis in a representative sample of people with diagnosed coeliac disease in the UK. Methods: Postal questionnaire of 2000 people with diagnosed coeliac disease, requesting information on date of diagnosis, type and duration of symptoms, and quality of life before and after diagnosis using the EQ-5D instrument. Results: The survey response rate was 40% (788/2000). Mean duration of symptoms prior to diagnosis was 13.2 years, with some evidence of shorter duration in recent years. Respondents reported a mean of 13 consultations with their GP about their symptoms prior to diagnosis. The mean utility value of pre-diagnosis quality of life was 0.56, compared to 0.84 at time of survey, a highly statistically significant improvement of 0.27 (95% c.i. 0.25, 0.30). Conclusions: The symptoms of undiagnosed coeliac disease are associated with a prolonged and substantial decrement to quality of life. These results strengthen the case for detailed examination of the cost-effectiveness of improved methods of detection and diagnosis, including population screening

Topics: RA Public aspects of medicine
Publisher: BioMed Central Ltd.
Year: 2010
DOI identifier: 10.1186/1472-6963-10-105
OAI identifier:
Provided by: LSE Research Online

Suggested articles


  1. (1996). A: The time trade-off method: results from a general population study. Health Econ doi
  2. (1999). Coeliac disease in primary care: case finding study. Br Med J doi
  3. (2003). Coeliac disease. Lancet doi
  4. (2006). Cost-effectiveness analysis of screening for Celiac disease in the adult population. Med Decis Making doi
  5. Disease: Recognition and assessment of Coeliac Disease. doi
  6. (2002). Estimating utility values for health states of type 2 diabetic patients using the EQ-5D (UKPDS 62). Med Decis Making doi
  7. (2004). et al.: Effect of an oats-containing gluten-free diet on symptoms and quality of life in coeliac disease. A randomized study. doi
  8. (1990). EuroQol - a new facility for the measurement of healthrelated quality of life. Health Policy doi
  9. (1996). Health Survey for England doi
  10. (1996). How many hospital visits does it take before celiac sprue is diagnosed? doi
  11. (2001). JA: Diagnostic approach to a patient with suspected celiac disease - A cost analysis. Digestive Diseases and Sciences
  12. (2000). JL: Validation study of retrospective recall of disease-targeted function - Results from the prostate cancer outcomes study. Med Care doi
  13. (1999). Lohiniemi S: Quality of life of celiac patients living on a glutenfree diet. Nutrition
  14. (2007). Retrospective baseline measurement of self-reported health status and health-related quality of life versus population norms in the evaluation of post-injury losses. Injury Prevention doi
  15. (2002). Screening for coeliac disease in type 1 diabetes. doi
  16. (2003). Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut doi
  17. (2006). The impact of a gluten-free diet on adults with coeliac disease: results of a national survey. doi
  18. (2008). to the methods of technology appraisal London: National Institute for Clinical Excellence; doi
  19. (2004). Undiagnosed coeliac disease at age seven: population based prospective birth cohort study. Br Med J doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.