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Photoacoustic imaging of blood vessel equivalent phantoms

By Beard Pc


Various phantoms have been used to assess the ability of transmission mode photoacoustic imaging to visualise blood vessels. A Q switched Nd:YAG laser operating at 1.06µm was used as the pulsed excitation source. The surface distribution of the photoacoustic signals was mapped by mechanically scanning a photodiode across the reflected output beam of a Fabry Perot polymer film ultrasound sensor. The depth profile of a 1.3mm thick polymer sheet (µa=0.8mm-1) immersed to a depth of 2cm in an Intralipid scattering solution (µs ’ =1mm-1, µa=0.03mm-1) was imaged using a 1D detector scan and a simple line-of-sight approach to image reconstruction. An arrangement comprising three 3 lines of PMMA tubing of internal diameter 62.5µm, arranged at different heights and filled with human blood, was immersed to depths of up to 7mm in the Intralipid solution. Using a radial backprojection algorithm, 2D and 3D images were reconstructed from 1D and 2D detector scans respectively. The “vessels ” could be observed as high contrast features on the images. Lateral resolution, limited by the detector aperture was 0.33mm and the axial resolution was 0.15mm

Topics: Photoacoustic, thermoacoustic, imaging, microvasculature, ultrasound array, biomedical, Fabry Perot
Year: 2011
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